targetmol metabolites Search Results


gsk2983559  (TargetMol)
91
TargetMol gsk2983559
<t>GSK2983559</t> improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells ( D – F ) and primary cultured astrocytes ( H – J ) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells ( G ) and primary cultured astrocytes subjected to OGD/R ( K ). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group
Gsk2983559, supplied by TargetMol, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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standards  (TargetMol)
92
TargetMol standards
<t>GSK2983559</t> improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells ( D – F ) and primary cultured astrocytes ( H – J ) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells ( G ) and primary cultured astrocytes subjected to OGD/R ( K ). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group
Standards, supplied by TargetMol, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
standards - by Bioz Stars, 2026-04
92/100 stars
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targetmol metabolites  (TargetMol)
93
TargetMol targetmol metabolites
<t>GSK2983559</t> improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells ( D – F ) and primary cultured astrocytes ( H – J ) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells ( G ) and primary cultured astrocytes subjected to OGD/R ( K ). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group
Targetmol Metabolites, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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data gut microbial metabolites dataset han  (TargetMol)
94
TargetMol data gut microbial metabolites dataset han
<t>GSK2983559</t> improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells ( D – F ) and primary cultured astrocytes ( H – J ) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells ( G ) and primary cultured astrocytes subjected to OGD/R ( K ). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group
Data Gut Microbial Metabolites Dataset Han, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
data gut microbial metabolites dataset han - by Bioz Stars, 2026-04
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Image Search Results


GSK2983559 improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells ( D – F ) and primary cultured astrocytes ( H – J ) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells ( G ) and primary cultured astrocytes subjected to OGD/R ( K ). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group

Journal: Journal of Neuroinflammation

Article Title: OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2

doi: 10.1186/s12974-023-02968-7

Figure Lengend Snippet: GSK2983559 improved stroke outcomes after cerebral ischemia. WT mice were subjected to 24 h MCAO. GSK2983559, an inhibitor of RIP2 was intraventricularly administered to mice 30 min before MCAO. A Neurological deficit scores. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. B Representative photographs of coronal brain sections following infarction, stained with 2, 3, 5-triphenyltetrazolium chloride (TTC). C Summary of cerebral infarct volume in brains. The infarct volume was expressed as the percentage of the contralateral hemispheric area. n = 8 mice per group, two-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group. Western blot analysis of Phospho-NF-κB p65 and IκBα protein levels in BV2 cells ( D – F ) and primary cultured astrocytes ( H – J ) after OGD/R. ELISA analysis of proinflammatory cytokine (IL-6 and TNF-a) production in supernatant of BV2 cells ( G ) and primary cultured astrocytes subjected to OGD/R ( K ). Results are representative of three independent experiments, one-way ANOVA with Tukey’s multiple comparisons test. * P < 0.05 compared with indicated group

Article Snippet: GSK2983559 (TopScience, Cat. T5401) was purchased from TopScience.

Techniques: Staining, Western Blot, Cell Culture, Enzyme-linked Immunosorbent Assay